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Red wine compound piceatannol inhibits the development of fat cells

Posted on Monday, 16 April, 2012 by anthony

Piceatannol weight lossPiceatannol (3,4,3′,5′-tetrahydroxy-trans-stilbene), a metabolite of resveratrol found in red wine, grapes, rhubarb, passion fruit seeds, blueberries, and peanuts appears to inhibit adipogenesis – the process by which preadipocytes (immature fat cells) develop into adipocytes (mature fat cells) – in part through the inhibition of insulin receptor activity in preadipocytes (Kwon et al., 2012). The research suggests that piceatannol may therefore be beneficial for the treatment/prevention of obesity.

Why is the inhibition of adipogenesis important?

Any inhibition of adipogenesis is important since when adipocyte numbers increase significantly – as is the case with obesity - there is often a concomitant increase in the release of pro-inflammatory molecules, fatty acids and hormones which may lead to a permanent pro-inflammatory state. It is believed that the inflammation associated with obesity may play a significant role in a number of health conditions including, metabolic syndrome, type 2 diabetes, atherosclerosis, and nonalcoholic fatty liver disease.

Other health benefits of Piceatannol

Piceatannol has been shown to have a number of potential health benefits including: 1) the suppression of both the growth and metastasis (spread) of cancer cells (Kita et al., 2012; Vo et al., 2010; Kim et al., 2009; Woolter et al., 2002); 2) beneficial effects in the treatment of some cardiovascular diseases (Woo et al 2010); 3) an anti-atherosclerotic effect and beneficial effects in the treatment of atherosclerosis (hardening of the arteries) (Choi et al 2010; Lee et al., 2009); 4) possible beneficial effects in the treatment of inflammatory bowel diseases (Kim et al., 2008), and; 5) protection against Beta-amyloid induced oxidative stress and cell death (Kim et al., 2007).

Piceatannol References

Choi KH, Kim JE, Song NR, Son JE, Hwang MK, Byun S, Kim JH, Lee KW, Lee HJ. (2010) Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells. Cardiovasc Res. 2010 Mar 1;85(4):836-44. Epub 2009 Nov 3.

Kim EJ, Park H, Park SY, Jun JG, Park JH. (2009) The grape component piceatannol induces apoptosis in DU145 human prostate cancer cells via the activation of extrinsic and intrinsic pathways. J Med Food. 2009 Oct;12(5):943-51.

Kim YH, Kwon HS, Kim DH, Cho HJ, Lee HS, Jun JG, Park JH, Kim JK. (2008) Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis. Int Immunopharmacol. 2008 Dec 10;8(12):1695-702. Epub 2008 Sep 4.

Kita Y, Miura Y, Yagasaki K. (2012) Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells. J Biomed Biotechnol. 2012;2012:672416. Epub 2012 Feb 8. doi:10.1155/2012/672416

Ko HS, Lee HJ, Kim SH, Lee EO. (2012) Piceatannol Suppresses Breast Cancer Cell Invasion through the Inhibition of MMP-9: Involvement of PI3K/AKT and NF-κB Pathways. J Agric Food Chem. 2012 Apr 13. [Epub ahead of print]

Kwon J Y, Seo S G, Heo Y-S, Yue S, Cheng J-X, Lee K W, and Kim K-H (2012) Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation J. Biol. Chem. 2012 287: 11566-11578. First Published on January 31, 2012, doi:10.1074/jbc.M111.259721

Lee B, Lee EJ, Kim DI, Park SK, Kim WJ, Moon SK. (2009) Inhibition of proliferation and migration by piceatannol in vascular smooth muscle cells. Toxicol In Vitro. 2009 Oct;23(7):1284-91. Epub 2009 Jul 22.

Vo NT, Madlener S, Bago-Horvath Z, Herbacek I, Stark N, Gridling M, Probst P, Giessrigl B, Bauer S, Vonach C, Saiko P, Grusch M, Szekeres T, Fritzer-Szekeres M, Jäger W, Krupitza G, Soleiman A. (2010) Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis. 2010 Dec;31(12):2074-81. Epub 2009 Aug 20.

Wolter F, Clausnitzer A, Akoglu B, Stein J. (2002) Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines. J Nutr. 2002 Feb;132(2):298-302.

Woo A, Min B, Ryoo S. (2010) Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity. Exp Mol Med. 2010 Jul 31;42(7):524-32.

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