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Creatine Monohydrates Antioxidant Properties Protect Against Oxidative Damage

Posted on Wednesday, 7 December, 2011 by anthony

Creatine Monohydrates Antioxidant Capacity

A recent research study provides further evidence to support creatine monohydrates antioxidant properties (Rahimi 2011). Previous studies have highlighted the antioxidant potential of creatine (Lawler et al., 2002; Royes et al., 2006; Sestili et al., 2011). In this study (Rahimi 2011) the researcher looked at whether creatine monohydrate could reduced oxidative stress by looking at two known markers of oxidative stress: 1) Malondialdehyde (MDA) - a highly reactive naturally occurring organic compound that is a marker for oxidative stress and indicates lipid peroxidation, and 2) 8-hydroxy-2-deoxyguanosine (8-OHdG) - a widely used biomarker for oxidative stress and carcinogenesis. It appears that creatines antioxidant properties may provide some protection against damage to DNA and lipids. 

In Summary:

In addition to the research proven benefits of creatine monohydrate on sporting performance it also appears to provide protection against the oxidative stress and oxidative damage induced by resistance exercise.


Lawler JM, Barnes WS, Wu G, Song W, Demaree S. (2002) Direct antioxidant properties of creatine. Biochemical and Biophysical Research Communications. 2002;290:47–52.

Rahimi R. (2011) Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. J Strength Cond Res. 2011 Dec;25(12):3448-55.

Royes LF, Fighera MR, Furian AF, Oliveira MS, Myskiw Jde C, Fiorenza NG, Petry JC, Coelho RC, Mello CF. (2006) Effectiveness of creatine monohydrate on seizures and oxidative damage induced by methylmalonate. Pharmacol Biochem Behav. 2006 Jan;83(1):136-44. Epub 2006 Feb 15.

Sestili P, Martinelli C, Colombo E, Barbieri E, Potenza L, Sartini S, Fimognari C. (2011) Creatine as an antioxidant. Amino Acids. 2011 May;40(5):1385-96. Epub 2011 Mar 15.

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